Linear 1 3-diarylpropanoids
Medchemexpress LLC 6-(4-(1-aminocyclobutyl)phenyl)-5-phenylnicotinamide | 1357158-81-6 | >98.0% | 343.42 g/mol | C22H21N3O | 10 MG
AKT-IN-1 is a small-molecule allosteric inhibitor of the AKT kinase family used for pathway and cancer research. It inhibits AKT with an IC50 of 1.042 μM, has CAS 1357158-81-6, and is supplied as a research-grade solid with high purity for biochemical and cellular assays.
- Allosteric AKT inhibition with IC50 = 1.042 μM.
- High chemical purity for reproducible results.
- Suitable for PI3K/Akt/mTOR pathway studies and cancer research.
- Solid form enabling flexible solution preparation.
- Molecular weight 343.42 g/mol and formula C22H21N3O for accurate dosing.
- Intended for research use only.
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 10MG
PI3K/AKT-IN-1 is a small-molecule dual inhibitor of the PI3K and AKT signaling pathways, intended for research use in cell signaling and oncology studies. It is supplied as a high-purity solid and is typically prepared in organic solvent for in vitro assays.
- Dual PI3K and AKT pathway inhibition for pathway modulation
- High reported purity suitable for biochemical assays
- Soluble in common organic solvents for assay preparation
- Suitable for cell-based signaling and apoptosis studies
- Characterized molecular data for analytical confirmation
Medchemexpress LLC Naringenin | 480-41-1 | MFCD00006844 | 272.25 | 100 MG
Naringenin, a predominant flavanone found in Citrus reticulata Blanco, exhibits strong anti-inflammatory and antioxidant activities. It also demonstrates anti-dengue virus (DENV) activity. Research indicates Naringenin can inhibit proliferation of HepG2 cells by inducing G0/G1 and G2/M phase accumulation and apoptosis. It also reduces viability of A431 cells and has shown potential to reduce plasma and liver triglycerides, cholesterol, and adiposity.
- Displays strong anti-inflammatory and antioxidant activities.
- Exhibits anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Induces G0/G1 and G2/M phase accumulation.
- Reduces A431 cell viability.
- Reduces plasma and liver triglycerides and cholesterol.
- Increases hepatic PPARα protein expression.
- Inhibits TNF-α-induced VSMC proliferation.
Medchemexpress LLC Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) | 4197-97-1 | 5 MG
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound isolated from Helichrysum Trilineatum. It facilitates AMP-activated protein kinase (AMPK) activation, which improves glucose tolerance, increases muscle fatty acid oxidation (FAO), and reduces fat accumulation in the liver and skeletal muscles of high-fat diet-induced (HFD) diabetic mice. These properties make Pinocembrin chalcone a promising compound for research related to gastric ulcers and diabetes.
- Antibacterial activity: Inhibits the growth of S. aureus in vitro.
- Metabolic regulation: Significantly increases the fatty acid oxidation rate and enhances the phosphorylation of AMPKα in C2C12 myotubes.
- Anti-diabetic effects: Improves glucose tolerance and reduces fat accumulation in the liver and muscles in HFD-induced diabetic mice.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 100 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that also possesses antioxidant and anti-inflammatory activities. It can improve adipocyte functions and inhibits histamine release from rat peritoneal mast cells.
- Inhibits histamine release from rat peritoneal mast cells.
- Improves adipocyte functions by enhancing adiponectin production.
- Stimulates the activity of PPARγ in cells.
- Inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated macrophages.
- Exhibits anti-allergic effects in type I allergic mice.
- Suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice.
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 5g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 10 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is for research use only.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates the expression and secretion of various adipokines.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory cytokines.
- Suitable for research use.
U.S. Pharmacopeia Avobenzone, 70356-09-1, MFCD00210252, 500mg
Molecular Formula C20H22O3, Molecular Weight 310.4, Melting Point 177.8 - 186.8 °F (81 - 86 °C), Flash Point > 200.00 °F (> 93.33 °C) Tag Closed Cup, Synonyms: 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-Propanedione, Butyl methoxydibenzoylmethane
